is not meant to be a substitute for professional medical advice, diagnosis or treatment. FDA Approves Remdesivir (Veklury) to Treat COVID-19. Statin drugs, also known as HMG-CoA reductase inhibitors, work by blocking the enzyme that your body needs to produce cholesterol. Grapefruit is a healthy food that is low in calories and high in vitamin C, antioxidants, and potassium. If you enjoy eating grapefruit, be sure to talk with your doctor or pharmacist about potential interactions with your medications. of their respective owners and rights holders and are used solely to represent the products Should patients avoid grapefruit juice consumption while taking widely used statins? If you take statin drugs for lowering cholesterol, it is a good idea to avoid grapefruit and grapefruit products. Grapefruit is a healthy food that is low in calories and high in vitamin C, antioxidants, and potassium. Has your provider ever warned you not to eat grapefruit if you take statins to treat high cholesterol? In the case of certain statins, grapefruit chemicals prevent them from being broken down. It is understandable that those who take statin drugs might want to add fresh grapefruit or grapefruit juice to their diets. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). Is It OK to Combine Lisinopril and Grapefruit? Coincidentally, the enzymes that break down some statins also interact with chemicals in grapefruits. Terms of Use. In the case of certain statins, grapefruit … It may be possible to switch to an alternative drug or lower your dosage so that you don't have to worry about the interaction between statins and grapefruit. Grapefruit can inhibit an enzyme in your liver that is needed to metabolize (breakdown) statins. If the body can't properly metabolize cholesterol … In essence, grapefruit chemicals can attach to liver enzymes and affect how those enzymes process medications. In of these rights holders. While grapefruit is a go-to healthy snack for many people, it contains a chemical called furanocoumarins which prevents enzymes in the body called CYP3A from breaking down certain types of statins. Coincidentally, the enzymes that break down some statins also interact with chemicals in grapefruits. Wikibuy Review: A Free Tool That Saves You Time and Money, 15 Creative Ways to Save Money That Actually Work. GoodRx is not offering advice, recommending or endorsing any specific prescription While you are taking this medicine, do not eat grapefruit or drink grapefruit juice at any time. Even if you eat or drink grapefruit products many hours after taking your pills, the risk is still present. The Statin-Grapefruit Interaction With some statins, a significant portion of the dose is destroyed in the digestive tract by a certain enzyme before it can be absorbed into the bloodstream. How about mixing pravastatin and vitamin C supplement? Fortunately, people who take statin drugs may not need to abstain from grapefruit or its juice forever. Why Do I Need Folic Acid When I’m Taking Methotrexate? Interestingly, the interaction between grapefruit … If you love grapefruit or grapefruit juice and your provider recommends that you start taking a statin, one of these may be a good option for you. If you take statin drugs for lowering cholesterol, it is a good idea to avoid grapefruit and grapefruit products. When this happens, it can cause unpleasant and even harmful side effects like muscle pain (also known as myopathy). What Are the Differences between Simvastatin and Pravastatin? GoodRx is not sponsored by or affiliated with any of the pharmacies identified in I hate the bitter taste of the fruit, so there is no danger of me forgetting about the interaction and eating it anyway. 7 Potential Side Effects of Albuterol Inhalers like ProAir, Ventolin, and Proventil, These 10 Prescription and OTC Medications Can Cause Heartburn and Hurt Your Esophagus. Copyright ©2020 GoodRx, Inc. Why Should I Not Combine Simvastatin and Grapefruit? Please seek medical advice before Get the best ways to save on your prescriptions delivered to your inbox. In fact, grapefruit can increase the risk for statin side effects by up to 5 times! discount cards, and is not required to register as a discount card provider. People taking statins should not ingest grapefruit. In essence, grapefruit chemicals can attach to liver enzymes and affect how those enzymes process medications. Grapefruit doesn’t affect other statins because they are metabolized by a different enzyme, CYP2C9. Statins and grapefruit are not the only significant drug/fruit interaction of which you need to be aware. drug, pharmacy or other information on the site. You may choose an alternative citrus beverage (such as orange juice). Grapefruit products, including grapefruit … The problem of toxic drug buildup similar to that caused by the interaction of statins and grapefruit can occur when people mix other drugs with fruits that contain bergamottin. Grapefruit juice contains compounds called furanocoumarins that … I used to eat grapefruit often, but I have gone without it for several years now. any of the pricing data or other information. Atorvastatin and simvastatin are the most widely prescribed statins in the U.S., so many people think the grapefruit restriction applies to all statins. Side effects of an interaction between statins and grapefruit include potentially fatal liver, kidney, and muscle damage. 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